Curcumin also inhibited the proliferation of MCF-7 breast cancer cells through Nrf2-mediated down-regulation of DNA repair-specific nuclease, Flap endonuclease 1 (Fen1)expression by reducing the Nrf2 recruitment to the Fen1 promoter (Chen et al., 2014). Here, NFE2L2 is linked to breast carcinoma.