The link to the pathogenesis of primary open-angle glaucoma (POAG) is suggested by elevated levels of ATX, LPA, and LPC in North American (in both Caucasians and African Americans) and Japanese POAG patients that correlated with elevation of intraocular pressure (IOP) (Honjo et al., 2018; Ho et al., 2020). This evidence concerns the gene ENPP2 and open-angle glaucoma.