Specifically, the CYP generated metabolite of arachidonic acid, epoxyeicosatrienoic acid (EET), has been shown to have cytoprotective effects for maintaining Akt and AMPK signaling in numerous cell lines and preventing insulin resistance in vivo in animal models subjected to high fat diets (Xu et al., 2013; He et al., 2016). The gene discussed is AKT1; the disease is Insulin resistance.