PPIG and Insulin resistance: Specifically, the CYP generated metabolite of arachidonic acid, epoxyeicosatrienoic acid (EET), has been shown to have cytoprotective effects for maintaining Akt and AMPK signaling in numerous cell lines and preventing insulin resistance in vivo in animal models subjected to high fat diets (Xu et al., 2013; He et al., 2016).