In concurrence with metabolic dysfunctions, overfeeding has been well accepted to trigger an inflammatory response, and the release of inflammatory factors such as TNF-α, IL-1β, CRP, and soluble adhesion molecules have also been causally linked to metabolic disorders (Hotamisligil et al., 1993; Herbert Haught et al., 1996; Koh et al., 2005; Ingelsson et al., 2008). The gene discussed is TNF; the disease is metabolic disease.