We observed that LRRK2 immunostaining in the colonic submucosa and lamina propria was significantly higher in patients with PD compared to controls [Figures 1D,E, controls vs. PD patients: 0.45 ± 0.39% (range 0.00–4.22%) vs. 0.81 ± 0.53% (range 0.01–5.03%); P = 0.02]. This evidence concerns the gene LRRK2 and Parkinson disease.