NLRP3 and Alzheimer disease: The present study was designed to verify whether: (1) the NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of AD; and (2) to examine if Sal can prevent neurons from damage in Aβ1-42 and D-gal/AlCl3-induced AD mouse models and D-gal-treated PC12 cell models through inhibited NLRP3 inflammasome-mediated pyroptosis.