NLRP3 and Alzheimer disease: As shown in Figure 10B, we found that the NLRP3 siRNA group or Salidroside significantly reversed D-gal induces upregulation of cleaved Caspase-1, GSDMD, IL-1β, and IL-18, further suggesting that NLRP3 inflammasome-mediated pyroptosis plays a central role in AD.