TNF and rheumatoid arthritis: The first module was mainly related to immunological regulation, immunological disorders, and pathogens infection (e.g., antigen processing and presentation, T-cell receptor signaling pathway and Th17 cell differentiation, tumor necrotic factor (TNF) signaling pathway, inflammatory bowel disease, influenza A, rheumatoid arthritis, Epstein-Barr virus infection, and herpes simplex infection).