IGKV1D-22 and cancer: As recent exhaustive reviews (Schuller, 2009; Grando, 2014; Schaal and Chellappan, 2014) have already considered the mechanisms by means of which nAChRs are involved in cancer signaling pathways, this review will concentrate on the latest published data concerning the role of α9/α9α10 (α9*) receptors in the physiology and pathology of lung, breast, glioblastoma, and melanoma cancers.