In the hippocampus of mice expressing human TAUP301L protein and AD patients with tauopathy, the TAU-injured neurons release the chemokine fractalkine CX3CL1 and an increase in the Nrf2 and HO-1 proteins levels (Lastres-Becker et al., 2014), suggesting an attempt of the diseased brain to limit microgliosis. This evidence concerns the gene HMOX1 and Alzheimer disease.