Nrf2 target genes such as NADPH quinone oxidoreductase I (NQO1), Heme oxygenase-1 (HO-1), and glutamate-cysteine ligase catalytic subunit (GCLC) expressions were observed in AD brains (Silva-Palacios et al., 2018). This evidence concerns the gene NFE2L2 and Alzheimer disease.