NFE2L2 and Alzheimer disease: Furthermore, Nrf2 deletion exacerbated the inflammatory response in AT mice as shown by increased proinflammatory factors and hippocampal astrogliosis and activation of microglia surrounding the Aβ plaque, and NFTs (neurofibrillary tangles) in AD animal models or human patients (Griffin et al., 1989; Simard and Rivest, 2006; Lok et al., 2013; Licht-Murava et al., 2016).