MAPT and Alzheimer disease: Alzheimer's disease (AD), the most common neurological disorder is an irreversible progressive neurodegenerative disease characterized by abnormal aggregation of amyloid β-peptide (Aβ), and hyperphosphorylated tau protein (p-tau) accumulation leading to the neuroinflammation, oxidative stress and a gradual loss in cholinergic, synaptic and cognitive functions (Li and Götz, 2017).