Lithium treatment also restored the number of NPC by stimulating the Wnt/β catenin pathway (Guidi et al., 2017), and increased the activity of GSK-3β in the cells by indirect interaction with the APP intracellular fragment (AICD), a molecule that is typically increased in DS (due to the triplicated APP gene) (Trazzi et al., 2014). This evidence concerns the gene APP and Dravet syndrome.