In addition, the interaction of the DISC1/GSK-3 complex with TRAX, impairs the ability to repair damaged DNA (Chien et al., 2018; Weng et al., 2018); Second, a polymorphism of the GSK-3β gene was shown to be associated with schizophrenia (Tang et al., 2013; Yan et al., 2016); Third, the GSK-3 regulation of circadian genes already described (Lamont et al., 2010) may be related to the sleep disturbances seen in schizophrenic patients (Taliercio et al., 2020). This evidence concerns the gene GSK3B and schizophrenia.