DISC1 and schizophrenia: In addition, the interaction of the DISC1/GSK-3 complex with TRAX, impairs the ability to repair damaged DNA (Chien et al., 2018; Weng et al., 2018); Second, a polymorphism of the GSK-3β gene was shown to be associated with schizophrenia (Tang et al., 2013; Yan et al., 2016); Third, the GSK-3 regulation of circadian genes already described (Lamont et al., 2010) may be related to the sleep disturbances seen in schizophrenic patients (Taliercio et al., 2020).