Studies have shown that MG are significantly active in the SNpc in PD mice, and that the secretion of inflammatory factors (TNF-α and IL-1β) is increased; these factors can attack the neurons and accelerate their degeneration and death, thus suggesting that activation of MG is one of the important links leading to the pathogenesis of PD (Bartels et al., 2020). This evidence concerns the gene IL1B and Parkinson disease.