Moreover, the NLRP3 inflammasome has been shown to be significantly activated in the substantia nigra of PD patients; the components of the NLRP3 inflammasome in MG were also up-regulated, including NLRP3, ASC, and the effector molecule Caspase-1 (Haque et al., 2020). Here, NLRP3 is linked to Parkinson disease.