Our findings are consistent with previous studies using cone-rod homeobox (Crx) knockout mice as a mouse model of retinopathy (Iura and Udo, 2014) and late enucleated mice (Dyer and Weldon, 1975: strains from Balb/cJ, C57BL/6J, SEC/1reJ, DBA/2J, Swiss/CD) and rats (Klein and Brown, 1969). This evidence concerns the gene CRX and retinal disorder.