CD4 and myeloid sarcoma: In particular, autoreactive CD4 T cells and, to a lesser extent, CD8 T cells are involved in MS pathogenesis, infiltrating the CNS and showing specificity for CNS autoantigen sources such as myelin basic protein (MBP), proteolipid protein (PLP), and myelin oligodendrocyte glycoprotein (MOG) (Table 1; Olsson et al., 1992; Correale et al., 1995; Wallstrom et al., 1998).