Bradycardia during and after fatal seizures has also been observed in animal models of epilepsy, including in anesthetized cats (Wasterlain, 1974), and a number of mouse models of epilepsy (Kalume et al., 2013; Aiba and Noebels, 2015; Aiba et al., 2016; Nakase et al., 2016; Kim et al., 2018; Loonen et al., 2019), including mice with Scn8a mutations used in the present study (Frasier et al., 2016; Wengert et al., 2021; Wenker et al., 2021). The gene discussed is SCN8A; the disease is epilepsy.