In order to obtain a clear answer, we performed a systematic review and a meta-analysis of randomized controlled trials (RCTs) which evaluated the effects of statins in lowering CRP and hs-CRP levels in different types of CVDs, such as ACS, myocardial infarction (MI), coronary artery disease (CAD), unstable angina, heart failure, stable atherosclerotic plaque, and carotid artery stenting. The gene discussed is CRP; the disease is heart failure.