CD36 and Insulin resistance: Taken together, in the heart towards development of insulin resistance, increases in CD36-mediated fatty acid uptake precede and are causal to decreased rates of GLUT4-mediated glucose uptake, and culminalte into a juxtaposed subcellular localization of CD36 and GLUT4 in cardiomyocytes (with CD36 being mostly at the cell surface and GLUT4 mainly imprisoned intracellularly) as a further step towards overt diabetic cardiomyopathy.