The STING variants (V147L, N154S, V155 M, C206Y, R281Q, or R284G) that constitutively induced type I interferon response were identified in the SAVI patients (Liu et al., 2014; Jeremiah et al., 2014; Melki et al., 2017). Here, STING1 is linked to STING-associated vasculopathy with onset in infancy.