Another study [17] has investigated the putative diagnostic and prognostic features of MCM2, MCM4, and MCM6 in breast cancer and has demonstrated that all three of them can discriminate between luminal A and B subtypes and are associated with higher histological grades and more aggressive subtypes (including luminal B, HER2-positive, and triple-negative breast cancers [TNBC]) [17]. This evidence concerns the gene ERBB2 and breast cancer.