Patients with BLCA in the high-risk groups had the higher expression of PDCD1, PD-L1, Tim-3, CTLA4, TIGIT, and LAG3 than those in the low-risk groups, which indicated that the unfavorable prognosis of BLCA patients in high-risk groups might be owing to the immunosuppressive microenvironment. The gene discussed is LAG3; the disease is bladder transitional cell carcinoma.