CTLA4 and bladder transitional cell carcinoma: Patients with BLCA in the high-risk groups had the higher expression of PDCD1, PD-L1, Tim-3, CTLA4, TIGIT, and LAG3 than those in the low-risk groups, which indicated that the unfavorable prognosis of BLCA patients in high-risk groups might be owing to the immunosuppressive microenvironment.