In a recent comprehensive genomic profiling assay of 584 soft-tissue sarcomas of various histologic variants, only 12 cases (2%) showed SWI/SNF subunits alterations including inactivating mutations or genomic deletions, of which the most common mutated subunit was ARID1A (4; 0.7%), followed by PBRM1 (3; 0.5%), SMARCB1 (3; 0.5%), and ARID2 (2; 0.3%) [8]. The gene discussed is SMARCB1; the disease is soft tissue sarcoma.