Furthermore, high UBE2C mRNA expression showed a non-significant association with the LVI-negative BC in the METABRIC cohort (p = 0.221, HR = 1.43, 95% CI; 0.80–2.60; Supplementary Fig. 2A) and the TCGA cohort (p = 0.537, HR 1.21, 95% CI; 0.65–2.26; Supplementary Fig. 2B). Here, UBE2C is linked to breast cancer.