ERBB2 and neoplasm: High UBE2C mRNA expression was significantly associated with the presence of LVI (METABRIC cohort: p = 0.002, TCGA cohort: p < 0.001) and other factors characteristics of a poor prognosis, including larger tumour size (p < 0.001), high tumour grade (p < 0.001), ER and progesterone receptor (PR) negativity (p < 0.001) and HER2 positivity (p < 0.001; Table 1).