TARDBP and Alzheimer disease: Although Alzheimer’s disease (AD) and CVD are the major contributors of cognitive decline in the elderly and are widely studied, evidence suggests the co-occurrence of medial temporal lobe (MTL) changes are caused by the TAR DNA binding protein of 43 kDa (TDP-43) [2–4], also recently referred to as limbic-predominant age-related TDP-43 encephalopathy (LATE) [5].