Higher than expected frequencies of other types of cancers, such as head and neck squamous cell carcinoma (HNSCC), neural system tumors, GI cancer, breast cancer, and lung adenocarcinoma are reported in association with CDKN2A mutations, depending on the protein (either p14 or p16) affected [4]. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.