Along the line, a study concluded that SC express Hypoxia inducible factor 2A (HIF2A) which promotes their quiescence and prevent the MD via a mechanism including Spry 1 gene activation by HIF2A. The inhibition of HIF2A improves the regenerative capacity via enhanced cell proliferation and differentiation which might have a therapeutic value to promote muscle regeneration [54]. The gene discussed is EPAS1; the disease is Menkes disease.