Children and adolescents with obesity due to POMC or LEPR deficiency in these studies tended to have more impaired baseline QOL (mean [SD] PedsQOL total scores 53.3 [6.2] for children and 63.3 [29.1] for adolescents) than children with other chronic conditions, such as diabetes mellitus, cardiac disease and cancer, from other studies, with mean (SD) PedsQL total scores 80.4 (12.9), 77.5 (14.5), and 72.0 (16.1), respectively [33]. Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.