FBP1 and hepatocellular carcinoma: We previously identified both catalytic and non-catalytic mechanisms of FBP1-dependent tumor suppression in clear cell renal cell and hepatocellular carcinomas [20, 21], and a tumor suppressive role for FBP1 has been noted for pancreatic adenocarcinoma [22], ER-positive breast cancer [23], and gastric cancer [24].