This familial AD-causing mutation renders the amyloid precursor protein (APP) a more favorable substrate for cleavage by β-secretase (BACE-1), causing increased production of amyloid beta (A \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β) [35]. Here, BACE1 is linked to Alzheimer disease.