VIP and acute respiratory distress syndrome: We hypothesized that this could be related to elevated VIP expression in the serum and bronchoalveolar lavage fluid (BALF) and endeavored to further investigate the protective effects of this pseudoephedrine + emodin combination on rats with LPS-induced ALI, as well as the mechanisms underlying the regulation of inflammation and pulmonary edema via the VIP /cAMP/PKA pathway.