Otherwise, the mRNA expression of LAG3, CTLA4, PD-1, PD-L1, and HAVCR2, tightly related to tumor immunosuppression or tolerance, were not significant differences in ACC with CENPFhigh, compared with CENPFlow (Fig. 7d, all p > 0.05). The gene discussed is HAVCR2; the disease is adrenal cortex carcinoma.