TP53 and adrenal cortex carcinoma: Accumulative literatures have demonstrated that inhibition of WNT–β-catenin signaling pathway [10], cell-cycle progression through down-regulation of p53–RB [11], defects in mismatch repair related enzymes (dMMR) [12], DNA methylation [13], and abnormal maintenance of telomere (ATRX [14, 15], DAX [16] and TERT [8, 17]), were closely bound up with the deterioration and poor prognosis of ACC.