As a powerful endogenous pyrogen, IL-1β can increase body temperature and cooperate with other inflammatory cytokines (such as TNF, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX) 2, and prostaglandin E2 (PGE2)) to cause inflammatory responses in multiple systems, which is associated with recurrent fever, multisystem inflammatory syndrome, and elevated acute-phase reactive proteins during the onset of SAIDs [12, 13]. This evidence concerns the gene NOS2 and Fever.