Other symptoms included polyarthralgia/arthritis in 18 patients (55%), abdominal pain/diarrhea in 16 patients (48%), rash in 15 patients (45%) (urticaria in 11 patients), lymphadenopathy/splenomegaly in 11 patients (33%), headache in 8 patients (24%), neurosensory deafness in 7 patients (21%), aphthous stomatitis in 4 patients (12%), and elevated acute-phase reactants such as C-reactive protein (CRP)/erythrocyte sedimentation rate (ESR) in 18 patients (55%). This evidence concerns the gene CRP and urticaria.