Wnt signaling is of great importance and it is common in lung cancer to have overexpression of Wnt-1/2/3/5a and other components (e.g. FZD, DVL, PORCN, TCF) [55, 56], which were predicted as the target genes for hsa_circ_0002360 (target genes: Wnt-2/3/5a/ FZD/DVL1/PORCN/TCF), hsa_circ_0003011 (target genes: FZD), hsa_circ_0008604 (target genes: Wnt-3/5a), hsa_circ_0009117 (target genes: Wnt-2/3/5a/FZD/DVL3/PORCN/TCF). Here, PORCN is linked to lung cancer.