To investigate the function of linc00261 in HCC, we constructed linc00261 stably overexpressionand transient knockdown models in 4 liver cancer cell lines (SMMC-7721 and Sk-hep1 for overexpression, Huh7 and MHCC-LM3 for transient knockdown; Fig. 2A). The gene discussed is LINC00261; the disease is hepatocellular carcinoma.