Our preview study had demonstrated that patients with low expression of linc00261 had a poor progression in HCC, and cells after linc00261 knockdown had increased migratory and invasive capabilities [22]; moreover, our another study revealed that linc00261 suppresses the formation of microvascular invasion, EMT, and metastasis of HCC through transcriptional upregulation of FOXA2 by recruiting SMAD3 to the FOXA2 promotor regions [23]. This evidence concerns the gene LINC00261 and hepatocellular carcinoma.