Overexpression of linc00261 significantly reduced the growth rates and tumor weights (Fig. 4B), and the IHC staining in xenograft tumors indicated that both the changes of expression of EMT-related (E-cadherin, Vimentin, Slug and ZEB1) and CSCs-related proteins (CD44, CD133, OCT4 and SOX2) were in accordance with in vitro assays (Fig. 4D, E). The gene discussed is PROM1; the disease is neoplasm.