The nanoplatform could dissociate into MOF-199 fragments by reacting with GSH in the tumor and release Vk3 that could be catalyzed by NAD(P)H quinone oxidoreductase-1(NQO1) to produce enough H2O2 to activate the Fenton-like reaction, as shown in Fig. 9c. Here, NQO1 is linked to neoplasm.