SLC5A2 and hydrops fetalis: In a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials, both of which investigated SGLT2 inhibitors in patients with chronic HF with reduced ejection fraction (HFrEF), SGLT2 inhibitors resulted in a 13% reduction in all-cause death, 14% reduction in cardiovascular death, 31% reduction in first hospitalization for HF, and 38% reduction in adverse renal outcomes in these patients [8].