Initiation of SGLT2 inhibitors in patients with AHF did not increase the risk AKI (OR 0.76; 95% CI [0.50, 1.16]; I2 = 10%; certainty: high), hypotension (OR 1.17; 95% CI [0.80, 1.71]; I2 = 0%; certainty: high), or hypoglycemia (OR 1.51; 95% CI [0.86, 2.65]; I2 = 0%; certainty: high; Fig. 4). This evidence concerns the gene SLC5A2 and Hypoglycemia.