Results from randomized clinical outcomes trials (RCTs) and meta-analyses of patients with heart failure (HF) have shown that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular (CV) outcomes in patients with chronic HF irrespective of diabetes status and across a wide spectrum of left ventricular ejection fraction [1–7]. The gene discussed is SLC5A2; the disease is diabetes mellitus.