Herein, we compared the immunological status of patients in our low- and high-risk groups, and assessed the relationship between the levels of difference prognostic PRGs in HNSCC (IL-6, NLRP1, NLRP2, NLRP3, NOD2, and PLCG1) and immune cell infiltration. Here, NLRP1 is linked to head and neck squamous cell carcinoma.