NLRP3 and neoplasm: RT-qPCR analyses of tumor tissues also supported the protective role of NLRP3 in the context of HNSCC development, while IHC analyses further highlighted the value of NLRP3 as a predictor of HNSCC patient prognosis, and the expression of NLRP3 was additionally shown to affect the invasion and migration of HNSCC cells.