In this study, we have analyzed common polymorphisms in genes involved in autophagy (ATG2B rs3759601, ATG16L1 rs2241880, ATG10 rs1864183, ATG5 rs2245214, NOD2 rs2066844 and rs2066845) in order to evaluate their role in the susceptibility to suffer glioblastoma. Here, ATG2B is linked to glioblastoma.