PROS1 and hyperinsulinemic hypoglycemia, familial, 4: It may also be caused by inherited or acquired thrombophilic disorders, including hyperhomocysteinemia, the factor V Leiden (FVL) mutation, the prothrombin G20210A mutation, antithrombin III deficiency, protein C deficiency, protein S deficiency, and the lupus anticoagulant found in antiphospholipid syndrome.