To relate our findings to COVID-19, we re-visited the global gene expression profiles of kidney in mice with pneumonia and mechanical ventilation [10, 11] with the main focus on changes in two important COVID-19 related genes angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). The gene discussed is TMPRSS2; the disease is pneumonia.