Using the β of multivariate analysis, we constructed a prognostic gene signature containing the five GRGs to predict the OS for each HCC patient as follows: risk score = (0.134 * expression level of ABCB6) + (0.072 * expression level of ANKZF1) + (0.031 * expression level of B3GAT3) + (0.150 * expression level of KIF20A) + (0.034 * expression level of STC2). The gene discussed is B3GAT3; the disease is hepatocellular carcinoma.