CD274 and cancer: For example, in patients with non-small cell lung cancer with high TMB (≥ 10 mut/MB), anti-PD-1/PD-L1 immunotherapy results in excellent outcomes regardless of PD-L1 expression levels In this study, we found that TMB of gastric cancer was the fourth highest among all kinds of cancer by bioinformatic analysis based on TCGA database, implying that GC could be considered as an immune-responsive tumor.