Since SNHG3 level was the highest in Du 145 cells and the lowest in LNCaP cells, we transfected oe-SNHG3 into LNCaP cells and transfected sh-SNHG3 into Du 145 cells to construct PCa cells with overexpressed and silenced SNHG3, thereby evaluating the biological role of SNHG3 in PCa (Fig. 2A). Here, SNHG3 is linked to posterior cortical atrophy.