CCK-8 assay was performed, and the results showed that cell viability of the sh-SNHG3 group in Met-Hcy+ medium and normal medium was markedly lower than that of the sh-NC group, while the ratio of cell viability of sh-SNHG3 + miR-152-3p inhibitor and sh-SNHG3 + oe-SLC7A11 groups in Met-Hcy+ medium and normal medium recovered (Fig. 6B), suggesting that silencing SNHG3 elevated methionine dependence of PCa cells. This evidence concerns the gene SNHG3 and posterior cortical atrophy.