Although significantly higher than healthy controls, no significant differences were found in plasma SOD levels among patients with ACLF caused by CHB, ALD, NAFLD and HCC (431.4 ± 16.91 U/mL vs 430.7 ± 23.24 U/m vs 371.9 ± 44.91 U/mL vs 479.5 ± 39.76 U/mL) at the time of hospital admission (Fig. 5d). Here, SOD1 is linked to metabolic dysfunction-associated steatotic liver disease.