Based on our results, we speculate that factors such as RECK and E2F1 in the MEbrown module directly affect the invasion and metastasis of EC through gene regulation, resulting in the occurrence of other malignant tumors, activation of proto-oncogenes in other parts through exosomes, or promotion of the metastasis of EC to other tissues through the tumor microenvironment. This evidence concerns the gene E2F1 and neoplasm.