Interestingly, of these 4 EAC-specific master TFs, GATA6 has been implicated as a key driver of the metaplastic transformation of esophageal tissue and survival of oncogenic BE populations,52,98,139, 140, 141, 142 with somatic variation at the GATA6 locus observed in a significant number of EAC cases according to the cancer genome atlas (TCGA) data. Here, GATA6 is linked to cancer.