The potency of effector immune cells, namely CD8+ T cells and NK cells, to identify and eliminate tumor targets is influenced by the presence of cells of the myeloid lineage, namely MDSCs and TAMs in the TME, which utilize several strategies to turn off the tumor-killing functions of NK cells and T cells (Ostrand-Rosenberg, Sinha, Beury, & Clements, 2012; Uzhachenko & Shanker, 2019). Here, CD8A is linked to neoplasm.