Of particular, the EGF-associated signaling pathways that include SRC family kinases, extracellular signal-regulated kinases (ERKs), and protein kinase B (AKT) pathways have been functionally associated with glucose metabolism and serine biosynthesis, for example, by driving the activation of PFK (11, 12, 13), hexokinase (9, 14) and phosphoglycerate kinase 1 (15) or the inhibition of pyruvate kinase (8, 16) in various cancer cells, as well as by promoting the upregulation of phosphoglycerate dehydrogenase (PHGDH) particularly in breast cancer cells (16, 17). The gene discussed is PHGDH; the disease is cancer.