CACNA1C and Brugada syndrome: Interestingly, there are CaVβ2 variants associated with Brugada syndrome that lead to decreased whole-cell currents (CaVβ2b_S481L) or accelerated inactivation of CaV1.2 (CaVβ2b_T11I) (Antzelevitch et al. 2007; Cordeiro et al. 2009).