CACNA1C and Timothy syndrome: Since the discovery that a single point mutation in the α1-subunit of L-type calcium channels (CaV1.2) causes Timothy syndrome, many other genes encoding voltage-gated calcium channel (VGCC) subunits have been associated with ASD like the genes CACNA1B-F encoding pore-forming subunits, CACNB1 and CACNB2 encoding auxiliary β-subunits and, CACNA2D3 and CACNA2D4 for auxiliary α2-δ-subunits (for a comprehensive overview, see Breitenkamp et al. 2015).