HTRA2 and osteosarcoma: For example, Sumo3, whose abundance decreased upon HtrA2 inhibition in the irradiated cells (Table S4), has been previously linked to senescence, and a Sumo3‐modified proteome was characterized following H‐Ras‐induced senescence in osteosarcoma cells, regulation of which had both pro‐ and anti‐senescent functions [51].