AKT1 and Hypertension: Oestrogens exert cardioprotective action through the prevention of cardiomyocyte apoptosis and oxidative stress in response to ischaemia/reperfusion injury and anthracycline damage.5, 29 The cardioprotective effect of oestrogens is also achieved in the presence of comorbidities including arterial hypertension, through the activation of the PI3K‐Akt pathway and Notch signalling.44