Although the physiological role of the FAM111B gene and gene mutations in POIKTMP are yet to be elucidated, recent studies have suggested that mutations may result in induced cytotoxicity resulting from the upregulation of a putative serine protease‐like domain in the FAM111B protein10 or the overexpression of the FAM111B gene product as seen in some adenocarcinomas.11 The gene discussed is FAM111B; the disease is adenocarcinoma.